2024 Approvals

Unlocking New Hope: Lazcluze and Amivantamab in the Battle Against Advanced Non-Small Cell Lung Cancer

Jasmine C

17 Nov 2025 — 1 min read

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What is the name of the drug and what does it do?

Lazcluze (pronounced laz-KLU-zay), generic name lazertinib, is a medicine used with another drug called amivantamab to treat adults with advanced or spreading non-small cell lung cancer (NSCLC). It is for patients whose cancer has specific changes in their EGFR gene, which helps the cancer grow.

How does it work?

Lazcluze blocks the EGFR protein, which is important for cancer cells to grow and survive. By stopping this protein, Lazcluze slows down or stops cancer growth. When used with amivantamab, it works even better to target and destroy cancer cells.

What did the research discover?

In clinical trials, Lazcluze combined with amivantamab helped patients live longer without their cancer getting worse. In one study, patients on this treatment had an average of 23.7 months before their cancer progressed, compared to 16.6 months for those on the standard treatment. It also shrank tumors in 78% of patients.

What are some of the side effects?

The most common side effects include:

Skin rash and changes to nails
Feeling tired
Diarrhea or constipation
Muscle or joint pain
Swelling in hands, feet, or face
Nausea
Mouth sores
Reactions to amivantamab infusions
Eye problems, like redness or irritation

Serious side effects can include blood clots, lung problems, and severe skin reactions.

What are the dosage recommendations and how is it prescribed?

Lazcluze is taken as a tablet once a day at a dose of 240 mg, with or without food. It is used along with regular infusions of amivantamab. If a dose is missed by more than 12 hours or if the patient vomits, they should skip that dose and take the next one as scheduled.

Source:

U.S. Food and Drug Administration. Full prescribing information: [Label for NDA 219008]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/219008s000lbl.pdf. Accessed 2024 Nov 20.

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