2025 Approvals

BLUJEPA(gepotidacin): FDA Approves New Treatment for Uncomplicated Urinary Tract Infections on March 25, 2025

Jasmine C

02 Oct 2025 — 1 min read

What is it prescribed for?

BLUJEPA is prescribed for the treatment of female adults and pediatric patients 12 years of age and older (weighing at least 40 kilograms, or 88 pounds) with uncomplicated urinary tract infections (uUTIs) caused by certain bacteria, including Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii complex, Staphylococcus saprophyticus, and Enterococcus faecalis.

What is the name of the drug and what does it do?

The brand name is BLUJEPA (pronounced "blu-JEP-ah"), and the generic name is gepotidacin. BLUJEPA treats bladder infections, specifically uncomplicated urinary tract infections, by targeting the bacteria causing the infection.

How does it work?

BLUJEPA is a type of antibiotic that works by blocking bacterial enzymes called topoisomerase II (DNA gyrase) and topoisomerase IV. These enzymes are necessary for bacterial DNA to replicate. By stopping them, BLUJEPA kills the bacteria and helps clear the infection.

What did the research discover?

In clinical trials, BLUJEPA was found to be just as effective as nitrofurantoin, a standard treatment for bladder infections:

In two major studies, BLUJEPA showed a composite response rate (meaning both clinical cure and bacterial eradication) that was similar or slightly better than nitrofurantoin.
For example, in one trial, 58.9% of patients treated with BLUJEPA achieved full resolution compared to 44.0% for nitrofurantoin.
Patients treated with BLUJEPA also had good outcomes across different bacteria types, especially for Escherichia coli, the most common cause of urinary tract infections.

What are some of the side effects?

Common side effects (occurring in 1% or more of patients):

Diarrhea
Nausea
Abdominal pain
Flatulence (gas)
Headache
Soft stools
Dizziness
Vomiting
Vulvovaginal candidiasis (yeast infection)

What are the dosage recommendations and how is it prescribed?

BLUJEPA is taken by mouth:

The recommended dosage is 1,500 mg (two 750 mg tablets) taken twice daily (about 12 hours apart) for 5 days.
It should be taken after a meal to help prevent stomach upset.
Patients should not double doses if a dose is missed and should complete the full course to ensure effectiveness.

Source:

GlaxoSmithKline. BLUJEPA (gepotidacin) tablets. Prescribing Information. 2025. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/218230s000lbl.pdf

Racial Gaps in Stroke Treatment: Who Gets Life-Saving Care?

What Did the Research Discover? This study looked at racial differences in the use of mechanical thrombectomy (MT)—a procedure that removes blood clots from the brain in people experiencing a stroke. Researchers analyzed 889,309 stroke cases in U.S. hospitals between 2006 and 2014 and found that only

Progress with Artificial Retina Implants in Patients with Macular Degeneration

Macular degeneration and retinitis pigmentosa are two major causes of vision loss, and both damage the retina—the layer in the back of the eye that captures light and sends signals to the brain. Once those photoreceptors, called rods and cones, are lost, vision declines. But new research shows that

Don’t Toss Them—Here’s How to Safely Dispose of Unused Medicines

Is your medicine cabinet full of expired drugs or medications you no longer use? The best way to dispose of most types of expired, unwanted or unused medicines is through a drug take-back program. To discard of your prescription or over-the-counter medicines, you can: If you cannot use those options,

Music May Help Lower Dementia Risk in Older Adults, A New Study Suggests

The Connection Between Music and Brain Health As people live longer, more families worry about memory loss and dementia. Scientists are working hard to understand how lifestyle habits—like staying active, socializing, and learning new skills—may help protect the brain. One area that has gained attention is music. Many